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It is necessary to clarify the heterogeneity of MM and identify new Apr 6, 2025 · In this study, we applied single-cell multiomics and gene regulatory network (GRN) analysis to characterize the transcriptional dynamics and clonal evolution of BCMA-targeted CAR T cells in longitudinally collected bone marrow (BM) and peripheral blood (PB) samples from MM patients. Descubre las mejores plantillas de diseño y crea imágenes sorprendentes en minutos. Today's top 15,000+ jobs in Rochester. Canva es una herramienta de diseño gráfico en línea gratuita. Nov 14, 2024 · Canva es una plataforma de diseño gráfico que te permite crear todo tipo de proyectos visuales: desde presentaciones y publicaciones para redes sociales hasta currículums y carteles publicitarios. Sep 14, 2024 · Multiple myeloma (MM) is a heterogeneous and incurable tumor characterized by the malignant proliferation of plasma cells. Empieza por tu cuenta o invita a otras personas a colaborar. com. Jan 9, 2025 · Leveraging a phase 1 clinical trial of the γ-secretase inhibitor (GSI), crenigacestat, with anti-BCMA CAR T cells (FCARH143), we used single-nuclei RNA sequencing and assay for transposase-accessible chromatin sequencing to characterize the effects of GSI on the tumor microenvironment. New Rochester jobs added daily. Apr 19, 2024 · We subjected mononuclear cells isolated from peripheral blood and bone marrow before and after the application of approved B cell maturation antigen-directed CAR T cells to single-cell 5 days ago · During a live event, Jorge Monge, MD, discussed real-world evidence on the use of CAR T-cell therapy beyond the trial setting in multiple myeloma. . Con Canva el diseño es fácil para todos. Puedes usarla para crear publicaciones para redes sociales, presentaciones, posters, videos, logos y mucho más. 3,920 Rochester Ny jobs available in Rochester, NY on Indeed. There are over 11,217 careers in rochester, ny waiting for you to apply! 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This study aims to uncover the molecular mechanisms of CART resistance by conducting single cell (sc) RNA-seq analysis on bone marrow (BM) samples from a R/R-MM patient undergoing BCMA CAR-T therapy clinical trials who finally relapsed 7 months later. 1000+ ROCHESTER, NY jobs ($19-$60/hr) from companies with openings that are hiring now. Apply today to land your dream job faster. Apply to Crew Member, Receptionist, Delivery Person and more! Search Full time jobs in Rochester, NY with company ratings & salaries. Con Canva, diseñar es fácil y gratis. See salaries, compare reviews, easily apply, and get hired. Jul 25, 2025 · In long-term results from the CARTITUDE-1 trial, investigators had found that the autologous cellular immunotherapy ciltacabtagene autoleucel was potentially curative for one-third of patients with heavily pretreated relapsed or refractory multiple myeloma. Find job listings near you & 1-click apply to your next opportunity! Aug 4, 2025 · Find local jobs in the greater Rochester, New York area, including Manufacturing, Healthcare & Human Services, Hotel Restaurant, Construction and Warehouse positions for both full-time and part-time. Jul 9, 2024 · These findings illustrate the power of single-cell approaches and provide insights into how the biology of CAR-Ts may affect outcomes in MM. 1 These patients remained progression-free for at least 5 years after a single infusion o Feb 3, 2021 · Here, we longitudinally profiled the transcriptomes of 55,488 T cells including CAR-T products, CAR-T cells, and endogenous T cells at the peak and remission phases in a plasma cell leukemia (PCL) patient treated with BCMA CAR-T cells by single-cell transcriptomic analysis. Because safety and efficacy can ultimately only be defined clinically, we selected approved and investigational targets for which clinical trail data are available. 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